Engraved frontis. port. of Jenner, engraved vignette on title, & four folding engraved plates, each finely hand-colored. 223, [2] pp. Large 4to, cont. vellum over boards (covers somewhat stained, upper hinge cracked but strong), spine gilt, red leather lettering piece on spine. Milan: Tipografia Mussi, 1809.

First edition. Sacco (1769-1836), was Italy’s first and most enthusiastic supporter of Jennerian vaccination and the first vaccinator in Lombardy, where smallpox was eliminated within three years. After Jenner’s own works, this is one of the most important early treatments of the subject and the first major Italian treatise on vaccination. It had an enormous effect in swaying... More